http://keralaheartjournal.in/ojs/index.php/KHJ/issue/feed 2017-09-04T18:54:15+00:00 Dr Sajeer K T editor@keralaheartjournal.in Open Journal Systems <p><strong>ISSN(Online):  2454-6755   </strong><strong>Open Access     No Author Charges</strong></p><p><strong></strong><strong>ISSN(Print):    <strong>2347-5269         </strong></strong></p><p><strong>Kerala Heart Journal indexed in:</strong></p><ol><li><a href="https://scholar.google.co.in/scholar?hl=en&amp;q=site%3Akeralaheartjournal.in&amp;btnG="><strong>Google Scholar</strong></a></li><li><strong><a href="http://www.journaltocs.ac.uk/index.php?action=search&amp;subAction=hits&amp;journalID=34275&amp;userQueryID=6313&amp;high=1&amp;ps=30&amp;page=1&amp;items=0&amp;journal_filter=&amp;journalby=">JournalTOCs, Heriot-Watt University Edinburgh, UK</a>,</strong></li><li><strong><a title="Kerala heart Journal" href="http://journalseeker.researchbib.com/?action=viewJournalseekerSearch" target="_blank">Research Bib</a> </strong></li><li><strong><a title="Kerala Hearrt Journal" href="http://www.drji.org/JustIncluded.aspx" target="_self">Directory of Research Journal indexing (DRJI</a>)</strong></li><li><strong><a href="http://journals.indexcopernicus.com/masterlist.php?q=kerala+heart+journal" target="_blank">Index Copernicus International </a></strong></li><li><strong><a title="DOAJ" href="https://doaj.org/search?source=%7B%22query%22%3A%7B%22filtered%22%3A%7B%22filter%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22term%22%3A%7B%22_type%22%3A%22journal%22%7D%7D%5D%7D%7D%2C%22query%22%3A%7B%22query_string%22%3A%7B%22query%22%3A%22kerala%20heart%20journal%22%2C%22default_operator%22%3A%22AND%22%7D%7D%7D%7D%2C%22from%22%3A0%2C%22size%22%3A10%7D" target="_blank">Directory of Open Access Journals</a>(DOAJ)</strong></li></ol><p><a title="Index Copernicus" href="http://journals.indexcopernicus.com/Kerala+Heart+Journal,p24783694,3.html?utm_source=SARE&amp;utm_medium=email&amp;utm_campaign=ICI+Journals+Master+List+2014" target="_blank"><strong>Kerala Heart Journal is listed at:</strong></a></p><ol><li><strong><a href="http://www.icmje.org/journals-following-the-icmje-recommendations/#K">International Committee of Medical Journal Editors (ICMJE)</a></strong></li></ol><p>Kerala Heart Journal (KHJ) is the official journal of Cardiological Society of India (CSI)-Kerala Chapter and accepts articles for publication from across the globe. Kerala Heart Journal is an open access multi indexed peer reviewed journal for updating cardiologists to newer developments in cardiology and for promoting cardiovascular research.  Kerala Heart Journal aims to publish work of the highest quality from all sub-specialties of cardiology-clinical and non-clinical including cardiovascular medicine and surgery. The editors of Kerala Heart Journal invite original research articles, review articles, case reports, cardiovascular images and letters to the editor for publication. All submitted manuscripts undergo a rigorous peer review process after submission. Currently Kerala Heart journal is published in two issues annually.<span>Uniform Requirements for Manuscripts Submitted to Biomedical Journals (</span><a href="http://www.icmje.org/">http://www.icmje.org</a><span>) will be followed. Please register and login for submitting manuscripts online.</span></p> http://keralaheartjournal.in/ojs/index.php/KHJ/article/view/136 2017-09-04T18:54:15+00:00 Royana Singh singhroyana@rediffmail.com

<p class="p9 ft7"><span class="ft6">Aim: </span>DCM is a major cause of morbidity and mortality which has a prevalence of one case out of 2500 individuals with an incidence of 7/100,000/year. The chief causes of DCM are heterogeneous including myocarditis, drug toxicity, and ischemia-induced, metabolic, mitochondrial, and genetic abnormalities. The study aims at the illustration of the mutation of the Delta sarcoglycan gene as a causative factor for DCM.</p><p class="p10 ft7"><span class="ft6">Methods: </span>Primers were designed for the coding region of δ-sarcoglycan gene. The assessment of DCM was based on strict diagnostic criteria requiring the presence of depressed left ventricular systolic function, associated with left ventricular dilation<span class="ft6">. </span>DNA was extracted from peripheral blood samples. The PCR was carried out followed by DNA sequencing.</p><p class="p11 ft9"><span class="ft8">Result: </span>Frame shift (deletion of T at position 95) and missense mutations (V140G) and (V156L) in the delta sarcoglycan was observed in patients with dilated cardiomyopathy.</p><p class="p12 ft12"><span class="ft10">Conclusion: </span>Novel mutations in the <span class="ft11">δ</span>-sarcoglycan gene maybe associated with DCM in north Indian population.</p>

2017-09-04T18:27:29+00:00 Copyright (c) 2017 Royana Singh